呼吸臨床

【特集】日本人が見つけた自己抗原・抗原

企画：宮崎泰成


　すべての疾患において，原因が明らかにされると疾患概念は変ってくる。特に，免疫アレルギー疾患においては，その疾患の原因である自己抗原や抗原が明らかになると，病態が明らかになり，最終的にはそれまでの診断や治療戦略が見直され大きく変わることがある。

石坂公成博士のIgEの発見を始め，日本人はアレルギー性疾患の分野で多大な貢献をして来た。本企画においては，各専門家の皆様に，日本人による自己抗原・抗原の発見がその疾患概念や診断・治療にどのような与えた影響を与えたかについて概説していただく。

スギ花粉症：スギ花粉の主なアレルゲン（Cry j 1とCry j 2）と都市部空中の挙動

王　青躍*

*埼玉大学大学院理工学研究科（〒338-8570 埼玉県さいたま市桜区下大久保255）


Major allergenic contents (Cry j 1 and Cry j 2) in Cryptomeria japonica pollen grains and the airborne behavior in urban atmosphere

Wang Qingyue*

*Graduate School of Science and Engineering, Saitama University, Saitama City


Keywords: スギ花粉症，Cry j 1とCry j 2，都市大気汚染，PM2.5，アレルゲン微粒子/Japanese cedar pollinosis, Cry j 1 and Cry j 2,  urban air pollution, PM2.5, allergenic fine particles


呼吸臨床 2017年1巻1号　論文No.e00016
Jpn Open J Respir Med　2017 Vol. 1 No. 1  Article No.e00016

DOI: 10.24557/kokyurinsho.1.e00016


掲載日：2017年10月28日


©️Wang Qingyue. 本論文の複製権，翻訳権，上映権，譲渡権，貸与権，公衆送信権（送信可能化権を含む）は弊社に帰属し，それらの利用ならびに許諾等の管理は弊社が行います。


要旨

　近年，都市部において，3.5人に1人がスギ花粉症患者と言われており，花粉飛散数が患者数に関わる原因と考えられてきた。しかしそれよりも，大気汚染物質の花粉表面への吸着や降水などと花粉との接触により，花粉粒が損傷・破裂され，アレルゲン（Cry j 1とCry j 2）が放出し，微小粒径へ移行・修飾する現象が観測されている。アレルゲンを含む複合的な微粒子が人体呼吸器系深部の肺胞にまで到達し，アレンゲン性の増悪によって花粉患者を苦しめており，花粉アレルゲンの情報化が求められている。本稿では，スギ花粉のアレルゲンの特徴に関する研究を紹介したうえで，都市部空中のスギ花粉・アレルゲン飛散実態に基づき，上述の問題を指摘し，国民に深く理解させると同時に，一部の対応策も紹介する。

文献

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