【特集】今日の薬剤性肺障害の実際■抗腫瘍薬：抗癌薬，分子標的治療薬，PDL-1など■柏田　建ほか |

【特集】今日の薬剤性肺障害の実際

企画：寺崎泰弘

　他誌などでも本特集テーマは時々ございますが，日進月歩の新しい治療薬に関連する，常に呼吸器領域の重要なテーマであります。新規薬剤に関する情報や鑑別に役立つ新知見などあればご紹介していただければと思います。

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抗腫瘍薬：抗癌薬，分子標的治療薬，PDL-1など

柏田　建，　齋藤好信

**日本医科大学大学院医学研究科呼吸器内科学分野（〒113-8603　東京都文京区千駄木1-1-5）

Drug-induced lung injury associated with anticancer agents

Takeru Kashiwada*, Yoshinobu Saito*

*Department of Pulmonary Medicine and Oncology, Graduate School of Medicine, Nippon Medical School, Tokyo

Keywords：薬剤性肺炎，抗腫瘍薬／drug-induced lung injury, anticancer agents

呼吸臨床 2020年4巻4号　論文No.e00086
Jpn Open J Respir Med 2020 Vol.4 No.4 Article No.e00086

DOI: 10.24557/kokyurinsho.4.e00086

掲載日：2020年4月14日

©️Takeru Kashiwada, et al. 本論文の複製権，翻訳権，上映権，譲渡権，貸与権，公衆送信権（送信可能化権を含む）は弊社に帰属し，それらの利用ならびに許諾等の管理は弊社が行います。

要旨

　近年，癌治療の抗腫瘍薬として，従来の殺細胞性抗癌薬に加え，分子標的薬，免疫チェックポイント阻害薬が臨床に導入されている。それに伴い，抗腫瘍薬による薬剤性肺障害の頻度は増加し，病型も多彩になっている。本稿では，肺癌治療の主要抗腫瘍薬における肺障害について，それぞれの頻度や病型，また近年のトピックスを概説する。また，薬剤性肺障害の最大のリスクである背景肺の間質性肺炎を合併した患者における，薬剤性肺障害への予防や対策についても記載する。

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